Triple Grand Slam winner Kerber won silver in women’s singles at the Rio 2016 Games.
The 33-year-old has had a busy turf season, having competed in three tournaments in the past month, winning at Bad Homburg and reaching the semi-finals at Wimbledon.
“Representing Germany in London 2012 and Rio 2016 on the German squad has always been one of my favorite memories of my career so far,” Kerber said in a statement.
– Angelique Kerber (@AngeliqueKerber) 1626352421000
“It makes it even more disappointing for me to accept that my body needs a rest after the intense few weeks behind me and that I need to recover first before returning to competition later this summer.
“Thank you for your support, as it was a very difficult decision for me. Good luck to all my fellow German athletes in Tokyo, I will miss you.”
A number of tennis big names will be missing from the Olympics, including Roger Federer, Rafa Nadal, Dominic Thiem, Serena Williams, Simona Halep and Bianca Andreescu.
British seeds Dan Evans and Johanna Konta will be sidelined after testing positive for COVID-19.